科技改变生活 · 科技引领未来
罗智,华中农业大学,教授、博导,水产养殖专家。研究方向:水产动物分子营养。一、简历1、教育经历1999年9月至2002年6月在大连水产学院(现大连海洋大学)学习,获农学硕士学位;2002年9月至2005年7月在中山大学生命科学学院学习,获理
罗智,华中农业大学,教授、博导,水产养殖专家。研究方向:水产动物分子营养。
一、简历
1、教育经历
1999年9月至2002年6月在大连水产学院(现大连海洋大学)学习,获农学硕士学位;
2002年9月至2005年7月在中山大学生命科学学院学习,获理学博士学位;
2、主要职历
2005年7月-至今,华中农业大学水产学院,先后任讲师(2005-2007)、副教授(2008-2013)和教授(2014-至今)。
2012年-2013年,英国University of St Andrews,访问学者。
2015年-2016年,美国Cornell University,访问教授兼唐氏学者。
罗智,华中农业大学,教授、博导,水产养殖专家。
二、科研项目
1、国家自然科学基金委员会,重点项目,32030111,鱼类锌稳态的调控机制及SUMO化修饰在锌稳态调控中的作用机理,2021-01至2025-12,278万(直接费用),在研,主持。
2、湖北省高等学校优秀中青年科技创新团队计划,T201933,水产动物分子营养创新团队。主持。
3、国家自然科学基金面上项目:31872585,金属反应转录因子-1(MTF-1)在铜和锌差异性影响黄颡鱼脂类代谢过程中的作用机制,2019/01-2022/12,61万元(直接费用),在研,主持。
4、国家重点研发计划“蓝色粮仓科技创新”重点专项:2018YFD0900400,水产动物精准营养及其代谢调控机制,2018/12-2022/12, 4015万元,在研,参加(课题负责人)。
5、国家重点研发计划“蓝色粮仓科技创新”重点专项:2018YFD0900600,重要养殖生物对典型环境胁迫的响应机制和生理生态效应研究,2018/12-2022/12, 3617万元,在研,参加。
6、 "973"计划, 2014CB138600,养殖鱼类蛋白质高效利用的调控机制,2014/01-2018/06,已结题,参加。
7、国家自然科学基金面上项目,31372547,水体铜和锌暴露差异性影响矛尾复虾虎鱼脂类代谢机理的比较研究,2014/01-2017/12,74万元,已结题,主持。
8、国家自然科学基金优秀青年科学基金,31422056,水产基础生物学,2015/01-2017/12, 100万元,已结题,主持。
9、国家自然科学基金面上项目,31000720,水体铜暴露诱导矛尾复虾虎鱼脂肪肝发生机理的研究,2011/01-2011/12,8万元,已结题,主持。
10、教育部新世纪优秀人才支持计划,NCET-08-0782,共轭亚油酸对矛尾复虾虎鱼脂肪沉积的影响及机理,2009/01-2011/12,50万元, 已结题,主持。
11、国家自然科学基金青年科学基金,308008050,自然海区矛尾复虾虎鱼脂肪肝病变发生的机理,2009/01-2011/12,19万元,已结题,主持。
12、“973”计划:2009CB118706,养殖池塘生态系统生物功能优化与水环境调控,2009/01-2013/12,已结题,参与。
三、论文发表
以第一作者和/或通讯作者发表论文152篇,其中在J Nutr(4篇)、Environ Sci Technol(2篇)、Food Chem(2篇)、Environ Pollut(3篇)、Cell Mol Life Sci、J Nutr Biochem和FASEB J等期刊发表SCI源刊论文137篇(“*”示通讯作者)。影响因子在5.0以上论文18篇(均为独立通讯作者)。
2021年度
152、Xu, X.J., Zhang, D.G., Zhao, T., Xu, Y.H., Luo, Z*, 2021. Dietary selenium (Se) sources differentially regulate Se concentration, mRNA and protein expression of representative selenoproteins in various tissues of yellow catfish Pelteobagrus fulvidraco. Br. J. Nutr., accepted.
151、Song, C.C., Chen, G.H., Zhong, C.C., Chen, F., Chen, S.W., Luo, Z.*, 2021. Transcriptional responses of four slc30a/znt family members and their roles in Zn homeostatic modulation in yellow catfish Pelteobagrus fulvidraco. Biochim Biphys Acta-Gene Regul Mechan, accepted.
150、Zhang, D.G., Zhao, T., Hogstrand, C., Ye, H.M., Xu, X.J., Luo, Z.*, 2021. Oxidized fish oils increased lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the CREB1-Bcl2-Beclin1 pathway in the liver tissues and hepatocytes of yellow catfish. Food Chem, 360, 129814.
149、Wei, X., Hogstrand, C., Chen, G., Lv, W., Song, Y., Xu, Y., Luo, Z*, 2021. Zn induces lipophagy via the deacetylation of Beclin1 and alleviates Cu-induced lipotoxicity at their environmentally relevant concentrations. Environ. Sci. Technol., 51, 4943-4953.
148、Xu, Y.H., Hogstrand, C., Xu, Y.C., Zhao, T., Zheng, H., Luo, Z.*, 2021. Environmentally relevant concentrations of oxytetracycline and copper increased liver lipid deposition through inducing oxidative stress and mitochondria dysfunction in grass carp Ctenopharyngodon idella. Environ. Pollut. 283, 117079.
147、Zhang, D.G., Zhao, T., Xu, X.J., Lv, W.H., Luo, Z.*, 2021. Dietary marginal and excess selenium increased triglycerides deposition, induced endoplasmic reticulum stress and differentially influenced selenoproteins expression in the anterior and middle intestines of yellow catfish Pelteobagrus fulvidraco. Antioxidants, 10, 535.
146、Wu, K., Chen, G.H., Hogstrand, C., Ling, S.C., Wu, L.X., Luo, Z.*, 2021. Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish. J. Trace Elem. Med. Biol., 65, 126732.
145、Zhao, T., Yang, S.B., Xu, Y.C., Chen, G.H., Xu, Y.H., Luo, Z.*, 2021. Phospholipase C signal mediated the glucose-induced changes of glucose absorption and lipid accumulation in the intestinal epithelial cells of yellow catfish Pelteobagrus fulvidraco. Br. J. Nutr., http://dx.doi.org/10.1017/S0007114521000350.
144、陈光辉,罗智*,2021。水产动物锌营养生理及其与脂类代谢相关研究进展。水产学报,45, 632-645.
2020年度
143、Zhuo, M.Q., Lv, W.H., Xu, Y.H., Luo, Z.*, 2020. Isolation and characterization of three sodium-phosphate cotransporter genes and their transcriptional regulation in the grass carp Ctenopharyngodon idella. Int. J. Mol. Sci., 21, 8228.
142、Chen, S.W., Wu, K., Lv, W.H., Chen, F., Song, C.C., Luo, Z.*, 2020. Functional analysis of two zinc (Zn) transporters (ZIP3 and ZIP8) promoters and their distinct response to MTF1 and RREB1 in the regulation of Zn metabolism. Int. J. Mol. Sci., 21, 6135.
141、Xu YH, Xu YC, Hogstrand C, Zhao T, Wu LX, Zhuo MQ, Luo Z*, 2020. Waterborne copper exposure up-regulated lipid deposition through the methylation of GRP78 and PGC1α of grass carp Ctenopharyngodon idella. Ecotoxicol. Environ. Saf., 205, 111089.
140、Chen GH, Zhao T, Wei XL, Zhang DG, Zhuo MQ, Luo Z*, 2020. miR-101b regulates lipid deposition and metabolism of primary hepatocytes in teleost yellow catfish Pelteobagrus fulvidraco. Genes, 11, 861.
139、Xu XJ, Zhang DG, Zhao T, Xu YH, Luo Z*, 2020. Characterization and expression analysis of seven selenoprotein genes in yellow catfish Pelteobagrus fulvidraco to dietary selenium levels. J. Trace Elem. Med. Biol., 62, 126600.
138、Song CC, Wu LX, Chen GH, Lv WH, Chen SW, Luo Z*, 2020. Six members of SLC30A/ZnTs family related with the control of zinc homeostasis: characterization, mRNA expression and their responses to dietary ZnO nanoparticles in yellow catfish. Aquaculture, 528, 735570.
137、Zhao, T., Yang, S.B., Chen, G.H., Xu, Y.H., Xu, Y.C., Luo, Z.*, 2020. Dietary glucose increases glucose absorption and lipid deposition via SGLT1/2 signaling and acetylated ChREBP in the intestine and isolated intestinal epithelial cells of yellow catfish. J. Nutr., 150, 1790-1798.
136、Xu YC, Xu YH, Zhao T, Wu LX, Yang SB, Luo Z*, 2020. Waterborne Cu exposure increased lipid deposition and lipogenesis by affecting Wnt/β-catenin pathway and the β-catenin acetylation levels. Environ. Pollut., 263, 114420.
135、Ling SC, Zhuo MQ, Zhang DG, Cui HY, Luo Z*, 2020. Nano-Zn increased Zn accumulation and triglyceride content by up-regulating lipogenesis in freshwater teleost, yellow catfish Pelteobagrus fulvidraco. Int. J. Mol. Sci., 21, 1615, doi: 10.3390/ijms21051615.
134、Song YF, Hogstrand C, Ling SC, Chen GH, Luo Z*, 2020. Creb-Pgc1α pathways modulates the interaction between lipid droplets and mitochondria and influences high fat diet-induced changes of lipid metabolism in the liver and isolated hepatocytes of yellow catfish. J. Nutr. Biochem. 80, 108364.
133、Wu K, Zhao T, Hogstrand C, Xu YC, Ling SC, Chen GH, Luo Z*, 2020. FXR-mediated inhibition of autophagy contributes to FA-induced TG accumulation and accordingly reduces FA-induced lipotoxicity. Cell Commun Signal, 18, 47.
132、Chen GH, Lv W, Xu YH, Wei XL, Xu YC, Luo Z*, 2020. Functional analysis of MTF-1 and MT promoters and their transcriptional response to zinc (Zn) and copper (Cu) in yellow catfish Pelteobagrus fulvidraco. Chemosphere, 246, 125792.
131、Chen SW, Wu K, Lv WH, Song CC, Luo Z*, 2020. Molecular characterization of ten zinc (Zn) transporter genes and their regulation to Zn metabolism in freshwater teleost yellow catfish Pelteobagrus fulvidraco. J. Trace Elem Med Biol, 59, 126433.
130、Chen G, Wu K, Zhao T, Ling S, Liu W, Luo Z*, 2020. miR-144 mediates high fat-induced changes of cholesterol metabolism via direct regulation of C/EBPα in the liver and isolated hepatocytes of yellow catfish. J. Nutr., 150, 464-474.
129、Zhao T, Wu K, Hogstrand C, Xu YH, Chen GH, Wei CC, Luo Z*, 2020. Lipophagy mediated carbohydrate-induced changes of lipid metabolism via oxidative stress, endoplasmic reticulum (ER) stress and ChREBP/PPARγ pathways. Cell Mol Life Sci, 77, 1987-2003.
2019年度
128、卓梅琴,杨水波,凌仕诚,罗智*,2019。饲料脂肪对黄颡鱼卵巢脂肪代谢以及PI3KCa甲基化和转录水平的影响。水产学报,43,2186-2196.
127、Wu LX, Wei CC, Yang SB, Zhao T, Luo Z*, 2019. Effects of fat and fatty acids on the formation of autolysosomes in the livers from yellow catfish Pelteobagrus fulvidraco. Genes, 10, 751, doi:10.3390/genes10100751.
126、Xu YH, Tan XY, Xu YC, Zhao T, Zhang LH, Luo Z*, 2019. Novel insights for SREBP-1 as a key transcription factor in regulating lipogenesis in a freshwater teleost, grass carp Ctenopharyngodon idella. Br. J. Nutr., 122, 1201-1211.
125、Li DD, Ling SC, Wu K, Luo Z*, 2019. Identification of five key genes involved in intrinsic apoptotic pathway from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to high fat diet. Front Physiol., 10, 921, doi: 10.3389/fphys.2019.00921.
124、Ling SC, Wu K, Zhang DG, Luo Z*, 2019. Endoplasmic reticulum stress-mediated autophagy and apoptosis alleviate dietary fat-induced triglyceride accumulation in the intestine and in isolated intestinal epithelial cells of yellow catfish. J. Nutr., 149, 1732-1741
123、魏晓雷,叶汉梅,罗智*,2019。黄颡鱼自噬相关基因LC3B和Beclin1的原核表达及多克隆抗体制备。水生生物学报,43,1197-1202。
122、Zhang DG, Cheng J, Tai ZP, Luo Z*, 2019. Identification of five genes in endoplasmic reticulum (ER) stress-apoptosis pathways in yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to dietary lipid levels. Fish Physiol. Biochem., 45, 1117-1127.
121、Pan YX, Zhuo MQ, Li DD, Xu YH, Wu K, Luo Z*, 2019. SREBP-1 and LXRα mediated Cu-induced hepatic lipid metabolism in zebrafish Danio rerio. Chemosphere, 215, 370-379.
120、张丽晗,罗智*,有文静,李丹丹,徐异桓,潘亚雄,2019. 黄颡鱼Wnt/β-catenin信号通路5个重要基因的识别及其在卵巢中的表达对铜暴露的响应。水产学报,43, 742-750。
2018年度
119、Luo Z*, Ye HM, Gao Y, Ling SC, Wei CC, Zhu XM, 2018. Chlorella additive increased growth performance, improved appetite and immune response of juvenile crucian carp Carassius auratus, Aquacult Res, 49, 3329-3337.
118、Yang SB, Tan XY, Zhang DG, Cheng J, Luo Z*, 2018. Identification of ten SUMOylation-related genes from yellow catfish Pelteobagrus fulvidraco, and their transcriptional responses to carbohydrate addition in vivo and in vitro. Frontiers in Physiology, 9, 1544, DOI: 10.3389/fphys.2018.01544.
117、Cui HY, Chen QL, Tan XY, Zhang DG, Ling SC, Chen GH, Luo Z*, 2018. MiR-205 mediated Cu-induced lipid accumulation in yellow catfish Pelteobagrus fulvidraco. Int J. Mol. Sci., 2018, 19, 2980; doi:10.3390/ijms19102980.
116、Song YF, Gao Y, Hogstrand C, Li DD, Pan YX, Luo Z*, 2018. Upstream regulators of apoptosis mediates methionine-induced changes of lipid metabolism. Cellular Signalling, 51, 176-190.
115、Song YF, Xu YH, Zhuo MQ, Wu, K., Luo Z*, 2018. CREB element is essential for unfolded protein response (UPR) mediating the Cu-induced changes of hepatic lipogenic metabolism in Chinese yellow catfish (Pelteobagrus fulvidraco). Aquat Toxicol., 203, 69-79.
114、Wu K, Luo Z*, Hogstrand C, Chen GH, Wei CC, Li DD, 2018. Zn stimulates the phospholipids biosynthesis via the pathways of oxidative and endoplasmic reticulum stress in the intestine of freshwater teleost yellow catfish. Environ. Sci. Technol., 52, 9206-9214.
113、Chen GH, Luo Z*, Hogstrand C, Wu K, Ling SC, 2018. SREBP1, PPARG and AMPK pathways mediated the Cu-induced change in intestinal lipogenesis and lipid transport of yellow catfish Pelteobagrus fulvidraco. Food Chem, 269, 595-602.
112、Wei CC, Luo Z*, Hogstrand C, Xu YH, Wu LX, Chen GH, Pan YX, Song YF, 2018. Zinc reduces hepatic lipid deposition and activates lipophagy via Zn2+/MTF-1/PPARα and Ca2+/CaMKKß/AMPK pathways. FASEB J, 32, 6666-6680.
111、Li DD, Luo Z*, Ling SC, Wu K, Chen GH, Cheng J, 2018. Mitochondrial apoptotic pathway mediated the Zn-induced lipolysis in yellow catfish Pelteobagrus fulvidraco. Chemosphere, 208, 907-915.
110、Wei CC, Luo Z*, Song YF, Pan YX, Zhuo MQ, 2018. Characterization of twelve autophagy-related genes from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to waterborne zinc exposure. Ecolog Indicat, 93, 677-686.
109、Chen GH, Luo Z*, Wei CC, Li DD, Pan YX, 2018. Six indicator genes for zinc (Zn) homeostasis in freshwater teleost yellow catfish Pelteobagrus fulvidraco: molecular characterization, mRNA tissue expression and transcriptional changes to Zn exposure. Biometals, 31, 527-537.
108、Pan YX, Luo Z*, Zhuo MQ, Wei CC, Chen GH, Song YF, 2018. Oxidative stress and mitochondrial dysfunction mediated Cu-induced hepatic lipid accumulation in zebrafish Danio rerio. Aquat Toxicol, 199, 12-20.
107、Zhuo MQ, Luo Z*, Xu YH, Li DD, Pan YX, Wu K, 2018. Functional analysis of promoters from three subtypes of the PI3K family and their roles in the regulation of lipid metabolism by insulin in yellow catfish Pelteobagrus fulvidraco. Int J. Mol. Sci., 19(1), 265; doi:10.3390/ijms19010265.
106、Ling SC, Luo Z*, Chen GH, Zhang DG, Liu X, 2018. Waterborne Zn influenced Zn uptake and lipid metabolism in two intestinal regions of juvenile goby Synechogobius hasta. Ecotoxicol Environ Saf, 148, 578-584.
105、罗智*,卓梅琴,2018. 鱼类胰岛素、胰岛素受体和胰岛素受体底物的生物学特性及其对营养物质代谢的调控. 水产学报,42, 149-158.
104、张丽晗, 罗 智*, 有文静, 李丹丹, 吴 坤, 潘亚雄, 2018. 黄颡鱼FZD家族4个基因的克隆、组织表达及对铜的响应研究. 水产学报, 42, 625-632.
103、张丽晗,罗智*,有文静,李丹丹,吴坤,徐异桓,2018。黄颡鱼Wnt家族4个基因的克隆、组织表达及对铜的响应。水生生物学报,42, 463-472。
2017年度
102、Xu YH, Luo Z*, Wu K, Fan YF, You WJ, Zhang LH, 2017. Structure and functional analysis of promoters from two liver isoforms of CPT I in grass carp Ctenopharyngodon idella. Int J Mol Sci, 18, 2405, doi: 10.3390/ijms18112405.
101、Cheng J, Luo Z*, Chen GH, Wei CC, Zhuo MQ, 2017. Identification of eight copper (Cu) uptake related genes from yellow catfish Pelteobagrus fulvidraco, and their tissue expression and transcriptional responses to dietborne Cu exposure. J Trace Elements Med Biol, 44, 256-265.
100、Li DD, Luo Z*, Chen GH, Song YF, Wei CC, Pan YX, 2017. Identification of apoptosis-related genes Bcl2 and Bax from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to waterborne and dietborne zinc exposure. Gene, 633, 1-8.
99、Chen GH, Hogstrand C, Luo Z*, Zhang DG, Ling SC, Wu K, 2017. Dietary zinc addition influenced zinc and lipid deposition in the fore- and mid-intestine of juvenile yellow catfish Pelteobagrus fulvidraco. Br J Nutr, 118, 570-579.
98、Song YF, Hogstrand C, Wei CC, Wu K, Pan YX, Luo Z*, 2017. Endoplasmic reticulum (ER) stress and cAMP/PKA pathway mediated Zn-induced hepatic lipolysis. Environ Pollut, 228, 256-264.
97、Zhuo MQ, Pan YX, Wu K, Xu YH, Luo Z*, 2017. Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco. Gen Comp Endocrinol, 247, 34-45.
96、Chen GH, Luo Z*, Chen F, Shi X, Song YF, You WJ, Liu X, 2017. PPARα, PPARγ and SREBP-1 pathways mediated waterborne iron (Fe)-induced reduction in hepatic lipid deposition of javelin goby Synechogobius hasta. Comp Biochem Physiol, Part C, 197, 8-18.
95、Shi X, Chen F, Chen GH, Pan YX, Zhu XM, Liu X, Luo Z*, 2017. Fishmeal can be totally replace by a mixture of rapeseed meal and Chlorella meal in diets for crucian carp (Carassius auratus gibelio). Aquacult Res, 48, 5481-5489.
94、Wei CC, Wu K, Gao Y, Zhang LH, Li DD, Luo Z*, 2017. Magnesium reduces hepatic lipid accumulation in yellow catfish (Pelteobagrus fulvidraco) and modulates lipogenesis and lipolysis via PPARA, JAK/STAT and AMPK pathways in hepatocytes. J. Nutr., 147, 1070-1078.
93、Wei CC, Luo Z*, Song YF, Pan YX, Wu K, You WJ, 2017. Identification of autophagy related genes LC3 and ATG4 from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to waterborne and dietborne zinc exposure. Chemosphere, 175, 228-238.
92、Shi X, Luo Z*, Chen GH, Chen F, Zhang LH, Zhu XM, Liu X, 2017. Replacement of fishmeal by a mixture of soybean meal and Chlorella meal in practical diets for juvenile crucian carp Carassius auratus. J World Aquacult Soc, 48, 770-781.
91、Zhuo MQ, Pan YX, Wu K, Xu YH, Zhang LH, Luo Z*, 2017. AKTs/PKBs: molecular characterization, tissue expression and transcriptional responses to insulin and/or wortmannin in yellow catfish Pelteobagrus fulvidraco. Fish Physiol Biochem, 43, 719-730.
90、Zhuo MQ, Pan YX, Wu K, Xu YH, Zhang LH, Luo Z*, 2017. IRS1 and IRS2: molecular characterization, tissue expression and transcriptional regulation by insulin in yellow catfish Pelteobagrus fulvidraco. Fish Physiol Biochem, 43, 619-630.
89、Luo Z*, Zou GY, Gao Y, Ye HM, Xi WQ, Liu X, 2017. Effect of dietary iron (Fe) levels on growth performance, hepatic lipid metabolism and antioxidant responses in juvenile yellow catfish Pelteobagrus fulvidraco. Aquacult Nutr, 23, 1475-1482.
88、Shi X, Luo Z*, Chen F, Wei CC, Wu K, Zhu XM, Liu X, 2017. Effect of fish meal replacement by Chlorella meal with dietary cellulase addition on growth performance, digestive enzymatic activities, histology and myogenic genes’ expression for crucian carp Carassius auratus. Aquacult Res, 48, 3244-3256.
87、Hu W, Mai KS, Luo Z*, Zheng JL, Chen QL, Pan YX, 2017. Effect of waterborne copper on lipid metabolism in hepatopancreas and muscle of grass carp Ctenopharyngodon idella. Aquacult Res, 48, 1458-1468.
86、Shi X, Luo Z*, Chen F, Huang C, Zhu XM, Liu X, 2017. Effects of dietary cellulase addition on growth performance, nutrient digestibility and digestive enzyme activities of juvenile crucian carp Carassius auratus. Aquacult Nutr, 23, 618-628
五、国内刊物发表的论文
6、谭肖英,罗智(通讯作者),王为民,熊邦喜,袁永超,樊启学,2009。饥饿对小规格斑点叉尾鮰体重及鱼体生化组成的影响。水生生物学报,33, 39-45.
5、Luo Z*, Li XD, Gong SY, Xi W, Li Y, 2009. Effect of dietary phosphorus on the growth and body components of juvenile Synechogobius hasta. J. Ocean Univ. China (Oceanic and Coastal Sea Research), 8, 65-70
4、Luo Z, Liu Y*, Mai K, Tian LX, Advances in the study on nutrient requirements of grouper (Epinephelus sp.): a review. J. Ocean Univ. China (Oceanic and Coastal Sea Research), 4, 93-98
3、罗智,刘永坚*,麦康森,田丽霞,刘栋辉,谭肖英,2004。石斑鱼配合饲料中发酵豆粕和豆粕部分替代鱼粉的研究。水产学报,28,175-181(英文)
2、罗智,刘永坚*,麦康森,田丽霞,2004。鱼类精氨酸需求研究进展。水产学报,28,450-459. (英文)
1、罗智*,李晓东,白海娟,袁勇超,龚世园,2008。野生和养殖矛尾复虾虎鱼营养组成和形态学的比较研究。上海水产大学学报,17,182-186.
张悦远